The timeline of metalloprotease events during oligofructose induced equine laminitis development
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چکیده
منابع مشابه
Distribution of technetium-99m PEG-liposomes during oligofructose-induced laminitis development in horses.
Liposomes are phospholipid nanoparticles used for targeted drug delivery. This study aimed to determine whether intravenous liposomes accumulate in lamellar tissue during laminitis development in horses so as to assess their potential for targeted lamellar drug delivery. Polyethylene-glycol (PEG) coated liposomes were prepared according to the film hydration method and labelled using (99m)Tc-he...
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REASONS FOR PERFORMING STUDY A previous preliminary study demonstrated the potential of distal limb cryotherapy (DLC) for preventing laminitis. Clinically, DLC must be effective for periods longer than 48 h and the preventive effect must extend beyond its discontinuation. OBJECTIVES To evaluate the effect of DLC, applied during the developmental phase of induced laminitis, on the severity of ...
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Although much has been written about laminitis in the context of its association with inflammatory processes, recognition is growing that most cases of laminitis examined by veterinarians in private practice are those associated with pasture grazing, obesity, and insulin resistance (IR). The term 'endocrinopathic laminitis' has been adopted to classify the instances of laminitis in which the or...
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Vasodilation precedes the development of carbohydrate overload laminitis. Circulating laminitis trigger factors activate lamellar enzymes, which lyse the attachments between the distal phalanx and the inner hoof wall. The clinical signs of laminitis occur when the lamellar architecture disintegrates. The amount of pain correlates with the extent of lamellar pathology. A substance produced by St...
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Over the past 20 yr, extensive research efforts as well as clinical experience has greatly increased our knowledge base of equine laminitis. Our present understanding of the disease is that there is failure of the lamellar attachment between the distal phalanx and hoof wall. This, in turn, initiates a sequence of events ranging from no permanent structural damage to loss of the hoof capsule. Af...
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ژورنال
عنوان ژورنال: Equine Veterinary Journal
سال: 2011
ISSN: 0425-1644
DOI: 10.1111/j.2042-3306.2011.00393.x